This game is being played at the Tottenham Hotspur Stadium and regular London visitors the Jaguars can put their local knowledge to good use. Liam Coen’s side are vastly improved since losing to the LA Rams at Wembley last season and the injury-hit Eagles are going through a rocky spell.

The final score of 23-12 hugely understated the Bears’ dominance over the Jets last week as they outgained their opponents by 492 yards to 157 and held the ball for 42 of the 60 minutes. The Packers have not been at all convincing this season despite recording two wins and the visitors offer value.

The Browns have won five of their last six and their young offensive stars are impressing under new head coach Todd Monken. It’s a surprise that they are underdogs against the Jets, who have lost three in a row and were outgained 492 yards to 157 by the Bears last week, and the visitors offer value.

The Patriots are strong at home and scored a late TD to upset the Bills in a key AFC East game last week, but the Raiders have made an impressive start to the season and can give another good showing. The Silver and Black have covered the handicap in all four of their games and can stay in touch.

The Saints were blown away by the Falcons in a 45-24 home defeat on Monday and they should struggle again when facing the unbeaten Vikings, who have the meanest defence in the NFL. The visitors are not in rhythm offensively yet but they can cover the small handicap.

The Lions have maintained their reputations as the NFL’s great entertainers with all four of their games this season producing at least 55 points and rewarding overs backers. The Cardinals’ last two losses have come by scores of 36-30 and 36-24, so they are capable of joining in the fun.

This is the game of the week in the NFL as the unbeaten 4-0 49ers head to the Super Bowl champions for a huge NFC West showdown in Seattle. The 49ers are on the road for the first time (apart from their Week 1 trip to Australia) but they look the best option with the handicap points on their side.

With Ravens QB Lamar Jackson an injury doubt for this game the Falcons are favourites as they seek a third win in a row and that looks justified. Kevin Stefanski’s team have come to life with two impressive wins since Michael Penix Jr returned at quarterback and RB Bijan Robinson is red hot.