The New York Jets are still winless at 0-6 and continue to struggle offensively, ranking near the bottom of the league in passing, penalties and sacks allowed. Despite playing at home in this one, the Jets have shown little advantage at MetLife, with lopsided losses and a fan base that appears to have checked out. Meanwhile, the Carolina Panthers have won 3 of their last 4 games and are showing signs of improvement, particularly from quarterback Bryce Young. Although the Panthers have yet to prove themselves on the road, this matchup presents a prime opportunity to do so against a struggling Jets squad and move to 4-3.

The New England Patriots sit atop the AFC East at 4-2 and are riding a 3-game winning streak, including a key road win over Buffalo. This week, they face the struggling 1-5 Tennessee Titans, who just fired head coach Bill Callahan after a string of poor performances and a lone, fluky win. While interim coaches sometimes spark a turnaround, Tennessee is clearly in a long-term rebuild with little to play for this season. With Drake Maye excelling at quarterback and the Patriots undefeated on the road, they are rightly favored and should comfortably cover this spread.

The Colts have been the surprise package of the season so far, starting 5-1, though they barely edged a depleted Cardinals team last week and failed to cover as 10-point favorites. They now visit Los Angeles for a tough matchup against the Chargers, who just ended a two-game skid with a narrow 29-27 win over Miami. Colts QB Daniel Jones and RB Jonathan Taylor have led the offense, while the Chargers continue to battle injuries, particularly at running back, though Kimani Vidal impressed last week. Despite the Colts’ hot start, they have had an extremely soft schedule and could be dealt a rude awakening in LA. The Chargers should hand Indianapolis its second loss of the season.

NFC East rivals collide as the Commanders and Cowboys face off in a crucial divisional matchup, with both teams looking to rebound from last-second losses last week. Washington blew a fourth-quarter lead to Chicago, while Dallas gave up a game-winning field goal to Carolina, continuing their defensive struggles. Commanders QB Jayden Daniels has sparked recent comebacks, while Dallas hopes to boost its high-powered offense with the return of WR CeeDee Lamb. With the Cowboys struggling defensively and Washington showing resilience, the Commies should be able to do enough to outscore Dallas.

The 49ers continue to add to their laundry list of injuries, with Fred Warner the latest casualty, but they showed encouraging signs in defeat to the Bucs last week and can bounce back here. Key players like George Kittle, Brock Purdy and Ricky Pearsall are trending toward returning, giving San Fran a boost heading into SNF. On the other side, Atlanta looked impressive in their win over Buffalo, but the result may be misleading given the Bills’ defensive breakdowns and a fluky start to the game. With the Falcons potentially overvalued and the 49ers getting healthier, this looks a solid bounce-back spot for the home team.

The Colts have been the surprise package of the season so far, starting 5-1, though they barely edged a depleted Cardinals team last week and failed to cover as 10-point favorites. They now visit Los Angeles for a tough matchup against the Chargers, who just ended a two-game skid with a narrow 29-27 win over Miami. Colts QB Daniel Jones and RB Jonathan Taylor have led the offense, while the Chargers continue to battle injuries, particularly at running back, though Kimani Vidal impressed last week. Despite the Colts’ hot start, they have had an extremely soft schedule and could be dealt a rude awakening in LA. The Chargers should hand Indianapolis its second loss of the season.

The Colts have been the surprise package of the season so far, starting 5-1, though they barely edged a depleted Cardinals team last week and failed to cover as 10-point favorites. They now visit Los Angeles for a tough matchup against the Chargers, who just ended a two-game skid with a narrow 29-27 win over Miami. Colts QB Daniel Jones and RB Jonathan Taylor have led the offense, while the Chargers continue to battle injuries, particularly at running back, though Kimani Vidal impressed last week. Despite the Colts’ hot start, they have had an extremely soft schedule and could be dealt a rude awakening in LA. The Chargers should hand Indianapolis its second loss of the season.

NFC East rivals collide as the Commanders and Cowboys face off in a crucial divisional matchup, with both teams looking to rebound from last-second losses last week. Washington blew a fourth-quarter lead to Chicago, while Dallas gave up a game-winning field goal to Carolina, continuing their defensive struggles. Commanders QB Jayden Daniels has sparked recent comebacks, while Dallas hopes to boost its high-powered offense with the return of WR CeeDee Lamb. With the Cowboys struggling defensively and Washington showing resilience, the Commies should be able to do enough to outscore Dallas.

The 49ers continue to add to their laundry list of injuries, with Fred Warner the latest casualty, but they showed encouraging signs in defeat to the Bucs last week and can bounce back here. Key players like George Kittle, Brock Purdy and Ricky Pearsall are trending toward returning, giving San Fran a boost heading into SNF. On the other side, Atlanta looked impressive in their win over Buffalo, but the result may be misleading given the Bills’ defensive breakdowns and a fluky start to the game. With the Falcons potentially overvalued and the 49ers getting healthier, this looks a solid bounce-back spot for the home team.