Ajax won the first leg 4-1 and with home advantage they can go one better against a limited opponent. Vojvodina may grab a consolation strike as Ajax struggled for clean sheets in Amsterdam towards the end of last season, so a 5-1 home win is the pick.

Coleraine have scored and conceded multiple goals in their last two home games while HJK have rattled in a total of 21 goals in their last six away trips. They can manage four again on the road as Coleraine struggle to keep pace with their classy attack in what could be an open game that ends with a 4-2 win for the visitors.

Hibs need a three-goal margin to go through in 90 minutes and may be capable of it if Malisheva sink too deep in a bid to protect their lead. Hibs scored exactly three goals in four of their final 12 home games last term, they could fight their way back into the tie and finish the job inside 90 minutes after their shock first leg loss.

HJK won the first leg 5-0 and it was never in doubt after they raced into an early lead. Coleraine have lost 13 of 23 home games in European competition and will probably be outclassed again with a few goals expected because five of Coleraine’s last seven matches have featured four or more goals – as have four of HJK’s last six away games.

Benfica were able to beat Real Madrid and Napoli at home in the Champions League last season, so could conceivably turn this tie around in Lisbon. St Gallen have struggled against established clubs in Europe in the past and have not kept a clean sheet in their last eight league games. But they did cause the Eagles’ defence enough problems at home to suggest they can score again in a potential 2-1 defeat.

At least three goals have been scored in all four of Ferencvaros’ competitive games this season and also in five of Twente’s last six games, including friendlies.

Valur won the first leg 1-0 but they rode their luck, Zrinjski won the shot count 16-7 and had 10 attempts on target to Valur’s two. With home advantage, The Bosnian side should be able to win and cover a -1 handicap to win this tie inside normal time.

Rijeka won the first leg 1-0 so this tie is very much alive and Derry should throw a bit of caution to the wind. The Candystripes have scored in each of their last five home games, hitting 12 goals in total, and can get on the scoresheet but Rijeka look the far stronger outfit and can finish this tie off with a win. 

Benfica were able to beat Real Madrid and Napoli at home in the Champions League last season, so could conceivably turn this tie around in Lisbon. St Gallen have struggled against established clubs in Europe in the past and have not kept a clean sheet in their last eight league games. But they did cause the Eagles’ defence enough problems at home to suggest they can score again in a potential 2-1 defeat.

Bohs needed a comeback to win the first leg but ultimnatelky it was a deserved victory. The Irish side are in form and fully up to speed, whereas Balkani have endured a mixed start to the new season after limping over the line last term. An away win is predicted but Balkani should be expected to score. They only failed to score in one home league game last season and Bohs have conceded in six of their last nine road games.

HJK won the first leg 5-0 and it was never in doubt after they raced into an early lead. Coleraine have lost 13 of 23 home games in European competition and will probably be outclassed again but they can at least grab a consolation effort. Coleraine have scored and conceded multiple goals in their last two home games while HJK have rattled in a total of 21 goals in their last six away trips.

Ajax dominated throughout in the first leg and should be able to win comfortably again but they may concede in victory, as they did last week in Serbia, as they have just one clean sheet in their last five home games.

Both sides look much better going forward than in defence and with Twente needing to push to overturn the deficit, they are taken to win and concede. Twente had 69% of the ball and double the number of shots Ferencvaros in the first leg, registering seven shots on target to Ferencvaros’ two, but the Twente rearguard was caught out by off-the-ball movement and suffered lapses in concentration. Otherwise, the Dutch side looked great in midfield and created plenty of chances through their wingers and full-backs. A repeat performance could easily turn the tie around in what should be another game where attack gets the better of defence.

Internacional have nine defeats in their 20 league games and have lost each of their last four. Flamengo have won three of their last four competitive games and the title contenders should be able to come away from Porto Alegre with all three points.

Remo have just one clean sheet in their last 12 trips but but they have scored themselves in five of their last six road games. Goals at both ends looks likely when they face a Mirassol side who have just one clean sheet in nine games – and are on a nine-game scoring streak at home.

Instituto have won four of their last five home games and can claim their first win of the Clausura when they host Platense, who have three defeats in their last six competitive away games.

Fluminense are unbeaten in seven at home, with five wins, but they have also conceded in their last 10 competitive games at the Maracana. Back Flu to win and concede against a Bahia side who have scored in eight of their last nine away from home.

Fluminense are unbeaten in seven at home, with five wins, but they have also conceded in their last 10 competitive games at the Maracana. Back Flu to win and concede against a Bahia side who have scored in eight of their last nine away from home.

Both teams have scored in five of HB’s last six home matches and they came close to grabbing one at Fir Park in the first leg too. Motherwell had an excellent away record last term, scoring in eight of their final nine Premiership road trips so back both teams to bag in Torshavn.

Rijeka won the first leg 1-0 so this tie is very much alive and Derry should throw a bit of caution to the wind. The Candystripes have scored in each of their last five home games, hitting 12 goals in total, and can get on the scoresheet but Rijeka look the far stronger outfit and are unlikely to draw a blank.

Valdemar Byskov Andreasen played for just 18 minutes in the first leg but he can play a key role in the return fixture. Andreasen opened his account for the season and provided an assist at Sonderjyske in 45 minutes at the weekend and he can follow that up with a goal against Besiktas on Wednesday.

Lenny Joseph has scored three goals in his last two games for Ferencvaros. The Haiti international looked very sharp in the first leg, converting two of four chances and registering both of his side’s two efforts on target.

Jhon Duran grabbed a goal and an assist in Benfica’s 5-1 friendly victory against Belenenses at the weekend after coming on at half-time. He will be desperate to impress a new set of fans and did score on his official debut for Al Nassr.

Bohs needed a comeback to win the first leg but ultimnatelky it was a deserved victory. The Irish side are in form and fully up to speed, whereas Balkani have endured a mixed start to the new season after limping over the line last term. The visitors are underdogs and they can pull off a minor upset with a win in Kosovo.

Midtjylland trail 1-0 after the first leg but they played the majority of that game with 10 men. The Danish side had a perfect home record in the league phase of the Europa League last season and can fight their way back into this tie by beating Besiktas, who have struggled on their travels in Europe in recent seasons.

Twente had 69% of the ball and double the number of shots Ferencvaros in the first leg, registering seven shots on target to Ferencvaros’ two, but the Twente rearguard was caught out by off-the-ball movement and suffered lapses in concentration. Otherwise, the Dutch side looked great in midfield and created plenty of chances through their wingers and full-backs. A repeat performance could easily turn the tie around in what should be another game where attack gets the better of defence.

The first leg finished 1-1 and a draw was a fair reflection on the game, and with home advantage in the return fixture Cluj look well placed to win and progress to the next round. The Romanian side won their home opener 5-0 this season and haven’t lost a competitive game at this venue since October, they can finish this tie off inside 90 minutes.

Rijeka won the first leg 1-0 so this tie is very much alive and Derry should throw a bit of caution to the wind. The Candystripes have scored in each of their last five home games, hitting 12 goals in total, and can get on the scoresheet but Rijeka look the far stronger outfit and can finish this tie off with a win. 

Benfica were able to beat Real Madrid and Napoli at home in the Champions League last season, so could conceivably turn this tie around in Lisbon. St Gallen have struggled against established clubs in Europe in the past and have not kept a clean sheet in their last eight league games. But they did cause the Eagles’ defence enough problems at home to suggest they can score again in a potential 2-1 defeat.

Fewer than four goals have been scored in nine of Hibs’ last 10 competitive games at Easter Road and fewer than four goals have been scored in six of Malisheva’s last seven away games.

Ajax won the first leg 4-1 and another high-scoring game is predicted. The Dutch side should be able to score heavily again and Vojvodina can add to the overall total as they struck in the first leg, and Ajax struggled for home clean sheets at the back end of last season. Over 3.5 goals has also landed in each of the visitors’ last three games.

At least three goals have been scored in all four of Ferencvaros’ competitive games this season and also in five of Twente’s last six games, including friendlies.

HJK won the first leg 5-0 and it was never in doubt after they raced into an early lead. Coleraine have lost 13 of 23 home games in European competition and will probably be outclassed again with a few goals expected because five of Coleraine’s last seven matches have featured four or more goals – as have four of HJK’s last six away games.

Bohs needed a comeback to win the first leg but ultimnatelky it was a deserved victory. The Irish side are in form and fully up to speed, whereas Balkani have endured a mixed start to the new season after limping over the line last term. The visitors are underdogs and they can pull off a minor upset with a win in Kosovo.

Benfica created enough chances to score twice in Switzerland but defended poorly and deserved to lose. Expect them to be better at home and they could be sharper in attack with Jhon Duran set to play some part. Back a 2-1 home win that would take the tie to extra time.

Hibs need a three-goal margin to go through in 90 minutes and may be capable of it if Malisheva sink too deep in a bid to protect their lead. Hibs scored exactly three goals in four of their final 12 home games last term, including two 3-0 wins.

Portsmouth spent last season battling the drop and seem set for another season of struggle. They have made some bold transfer moves but they have signed players unproven in this league, and don’t necessarily seem any stronger than they were last season so they are among the contenders to drop down to League One.

Cambridge won promotion last term and are yet to really strengthen their team. The U’s spend four years in League One before a campaign in League Two last term, and they only finished higher than 18th in one of those seasons. Of all the promoted teams, Cambridge are perhaps the most likely to drop straight back down.

Tranmere lost 20 of their final 26 games last season and only avoided the drop by two points. The two teams that came up from the National League should be competitive and that should result in an intense relegation fight, and Rovers look likely to be involved.